Expanding knowledge of other proteins associated with Alzheimer’s disease and other neurodegenerative diseases.

Mission

Establish a world-leading center utilizing mass spectrometry and other novel methods to discover neurodegenerative biomarkers in Alzheimer’s disease (AD) and related disorders.

The center aims to..

  • Better understand the causes of Alzheimer’s disease and other neurodegenerative disorders, primarily through aggregation of proteins in the brain and the role of these proteins in the disease process.
  • Develop and validate biomarkers for both diagnosis and prognosis.
  • Discover and implement simple and effective diagnostic tests for Alzheimer’s disease and related dementias.
  • Accelerate the development of new treatments for AD and related diseases.

Updates

  • First two SILQ Center faculty members joined, pilot & discovery projects ongoing, installation of major equipment established for first two phases
  • Major funds raised in partnership with The Foundation for BJH and the Tracy Family
  • Space for Center secured (new Neuroscience Research Building currently under construction)

News

New center’s aim: to ID biomarkers of neurodegenerative diseases (Links to an external site)

New center’s aim: to ID biomarkers of neurodegenerative diseases
A new center established at Washington University School of Medicine in St. Louis aims to accelerate research into biomarkers of neurodegenerative conditions such as Huntington’s and Parkinson’s diseases, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and the so-called tauopathies, a group that includes Alzheimer’s disease along with rarer diseases such as frontotemporal dementia, corticobasal syndrome […]

Blood test for Alzheimer’s highly accurate in large, international study (Links to an external site)

Blood test for Alzheimer’s highly accurate in large, international study
“A blood test for Alzheimer’s provides a huge boost for Alzheimer’s research and diagnosis, drastically cutting the time and cost of identifying patients for clinical trials and spurring the development of new treatment options,” Bateman said. “As new drugs become available, a blood test could determine who might benefit from treatment, including those at very early stages of the disease.”

Expected outcomes of the Neuro SILQ Center

  • Better understanding of the causes and progression of neurodegenerative diseases (e.g. Alzheimer’s, Parkinson’s, Lou Gehrig’s/ALS, etc.)
  • Discover new mechanisms of disease to enable specific treatment development for neurological diseases
  • Discover new biomarkers to identify disease before nervous system damage occurs (e.g. amyloid and tau blood test)
  • Personalized medicine – to identify the specific path causing disease in each individual
  • Internal growth of novel approaches
  • Investment from external investigators and groups
  • Development of methods for commercial spin-off

Impact of our partnerships

  • A combined blood tau and β-amyloid test can be used to detect Alzheimer’s disease amyloid plaques and tau tangles in individuals before symptom onset and predict when individuals may have symptom onset.
  • The combined blood tau and β-amyloid test can accelerate ongoing and future clinical trials, especially prevention trials, to speed drug discovery for Alzheimer’s disease prevention and treatments.
  • When effective drugs are found, the combined blood tau and β-amyloid test can be used to screen millions of people in the general public to identify who is at risk for Alzheimer’s disease and start treatments even before memory loss and brain damage begins.
  • Future phases:
    • Discover novel biomarkers to improve patient care and improve treatment options.
    • Determine the link between amyloid plaques and tangle formation to develop specific treatments (Personalized Medicine).
    • Develop novel approaches and assays for other disease pathologies such as Parkinson’s disease, Frontotemporal Dementia, ALS/Lou Gehrig’s disease.