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Two doses of an FDA-approved sleeping pill reduced levels of Alzheimer’s proteins in a small study of healthy volunteers led by researchers at Washington University School of Medicine in St. Louis. The study hints at the potential of sleep medications to slow or stop the progression of Alzheimer’s disease, although much more work needs to be done to confirm the viability of such an approach.

Bateman has been chosen to receive the honor for his groundbreaking work in Alzheimer’s research, including the development of plasma biomarkers in Alzheimer’s diagnostics. He will receive the award in October at the Clinical Trials on Alzheimer’s Disease conference in Boston.

Washington University School of Medicine in St. Louis and the pharmaceutical company Eisai Co. Ltd., headquartered in Japan, have formed a research collaboration aimed at developing new treatments for Alzheimer’s disease, Parkinson’s disease and other neurodegenerative conditions. The two organizations previously have partnered on Alzheimer’s clinical trials, and the new alliance combines their complementary efforts to identify and validate biomarkers and drug targets for a range of neurodegenerative conditions, with a goal of developing new drugs for the benefit of patients worldwide.

Sato and Horie led a team that discovered a biomarker for a rare, deadly brain disease known as corticobasal degeneration (CBD). The biomarker could accelerate efforts to develop treatments for CBD.

A new center established at Washington University School of Medicine in St. Louis aims to accelerate research into biomarkers of neurodegenerative conditions such as Huntington’s and Parkinson’s diseases, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and the so-called tauopathies, a group that includes Alzheimer’s disease along with rarer diseases such as frontotemporal dementia, corticobasal syndrome […]

“A blood test for Alzheimer’s provides a huge boost for Alzheimer’s research and diagnosis, drastically cutting the time and cost of identifying patients for clinical trials and spurring the development of new treatment options,” Bateman said. “As new drugs become available, a blood test could determine who might benefit from treatment, including those at very early stages of the disease.”

Scientists have devised a blood test to detect proteins that form the plaques in the brain that are suspected to cause Alzheimer’s. They believe this may lead to being able to diagnose Alzheimer’s before showing symptoms.

An international clinical trial aimed at finding treatments for Alzheimer’s disease has expanded to include investigational drugs targeting a harmful form of the brain protein tau. Originally focused on amyloid-based therapies, the trial launched with funding from the National Institute on Aging (NIA) of the National Institutes of Health (NIH) in 2013. Source: HEC Media

Clinical scientists at Washington University School of Medicine in St. Louis and University College London are collaborating with pharmaceutical companies AbbVie, Biogen, Bristol Myers Squibb and Roche to investigate the role of neurofilament light (NfL) chain in neurodegenerative diseases such as amyotrophic lateral sclerosis, Parkinson’s disease, Huntington’s disease and Alzheimer’s disease.

This collaborative effort between UCL, Washington University, and pharmaceutical companies such as AbbVie, Biogen, Bristol Myers Squibb and Roche aims to better understand the structure and role of NfL across different neurodegenerative diseases, including amyotrophic lateral sclerosis, Parkinson’s disease, Huntington’s disease and Alzheimer’s disease.