Featured publications
Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype
July 1, 2023
Lawler PE, Bollinger JG, Schindler SE, Hodge CR, Iglesias NJ, Krishnan V, Coulton JB, Li Y, Holtzman DM, Bateman RJ. Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype. Anal Biochem. 2023 Jul 1;672:115156. doi: 10.1016/j.ab.2023.115156. Epub 2023 Apr 16. PMID: 37072097.
Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer’s Disease
June 1, 2023
Horie K, Li Y, Barthélemy NR, Gordon B, Hassenstab J, Benzinger TLS, Fagan AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, Ikeuchi T, Kasuga K, Noble J, Farlow M, Chhatwal J, Day G, Schofield PR, Masters CL, Levin J, Jucker M, Lee JH, Roh JH, Sato C, Sachdev P, Koyama A, Reyderman L, Bateman RJ, McDade E; and the Dominantly Inherited Alzheimer Network. Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer’s Disease. Ann Neurol. 2023 Jun;93(6):1158-1172. doi: 10.1002/ana.26620. Epub 2023 Mar 16. PMID: 36843330; PMCID: PMC10238659.
Design and feasibility of an Alzheimer’s disease blood test study in a diverse community-based population
May 19, 2023
Li M, Li Y, Schindler SE, Yen D, Sutcliffe S, Babulal GM, Benzinger TLS, Lenze EJ, Bateman RJ. Design and feasibility of an Alzheimer’s disease blood test study in a diverse community-based population. Alzheimers Dement. 2023 May 19. doi: 10.1002/alz.13125. Epub ahead of print. PMID: 37204806.
CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease
April 1, 2023
Barthélemy NR, Saef B, Li Y, Gordon BA, He Y, Horie K, Stomrud E, Salvadó G, Janelidze S, Sato C, Ovod V, Henson RL, Fagan AM, Benzinger TLS, Xiong C, Morris JC, Hansson O, Bateman RJ, Schindler SE. CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease. Nat Aging. 2023 Apr;3(4):391-401. doi: 10.1038/s43587-023-00380-7. Epub 2023 Mar 13. PMID: 37117788; PMCID: PMC10154225.
Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS
March 10, 2023
Lucey BP, Liu H, Toedebusch CD, Freund D, Redrick T, Chahin SL, Mawuenyega KG, Bollinger JG, Ovod V, Barthélemy NR, Bateman RJ. Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS. Ann Neurol. 2023 Mar 10. doi: 10.1002/ana.26641. Epub ahead of print. PMID: 36897120.
Acute sleep loss decreases CSF-to-blood clearance of Alzheimer’s disease biomarkers
January 25, 2023
Liu H, Barthélemy NR, Ovod V, Bollinger JG, He Y, Chahin SL, Androff B, Bateman RJ, Lucey BP. Acute sleep loss decreases CSF-to-blood clearance of Alzheimer’s disease biomarkers. Alzheimers Dement. 2023 Jan 25. doi: 10.1002/alz.12930. Epub ahead of print. PMID: 36695437.
Recent publications
- Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriersDominantly Inherited Alzheimer Network (DIAN), Brase, L., You, S. F., D’Oliveira Albanus, R., Novotny, B. C., Soriano-Tarraga, C., Dykstra, T., Fernandez, M. V., Budde, J. P., Bergmann, K., Morris, J. C., Bateman, R. J., Perrin, R. J., McDade, E., Xiong, C., Kipnis, J., Karch, C. M., Benitez, B. A. & Harari, O., Dec 2023, In: Nature communications. 14, 1, 2314.Research output: Contribution to journal › Article › peer-review
- A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer’s diseaseMerrihew, G. E., Park, J., Plubell, D., Searle, B. C., Keene, C. D., Larson, E. B., Bateman, R., Perrin, R. J., Chhatwal, J. P., Farlow, M. R., McLean, C. A., Ghetti, B., Newell, K. L., Frosch, M. P., Montine, T. J. & MacCoss, M. J., Dec 2023, In: Scientific data. 10, 1, 206.Research output: Contribution to journal › Article › peer-review
- Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotypeLawler, P. E., Bollinger, J. G., Schindler, S. E., Hodge, C. R., Iglesias, N. J., Krishnan, V., Coulton, J. B., Li, Y., Holtzman, D. M. & Bateman, R. J., Jul 1 2023, In: Analytical Biochemistry. 672, 115156.Research output: Contribution to journal › Article › peer-review
- Unsupervised high-frequency smartphone-based cognitive assessments are reliable, valid, and feasible in older adults at risk for Alzheimer's diseaseNicosia, J., Aschenbrenner, A. J., Balota, D. A., Sliwinski, M. J., Tahan, M., Adams, S., Stout, S. S., Wilks, H., Gordon, B., Benzinger, T. L. S., Fagan, A. M., Xiong, C., Bateman, R. J., Morris, J. & Hassenstab, J., Jun 1 2023, In: Journal of the International Neuropsychological Society. 29, 5, p. 459-471 13 p.Research output: Contribution to journal › Article › peer-review
- Mitigating the Associations of Kidney Dysfunction with Blood Biomarkers of Alzheimer Disease by Using Phosphorylated Tau to Total Tau RatiosJanelidze, S., Barthélemy, N. R., He, Y., Bateman, R. J. & Hansson, O., May 8 2023, In: JAMA Neurology. 80, 5, p. 516-522 7 p.Research output: Contribution to journal › Article › peer-review
- Independent study demonstrates amyloid probability score accurately indicates amyloid pathologyFogelman, I., West, T., Braunstein, J. B., Verghese, P. B., Kirmess, K. M., Meyer, M. R., Contois, J. H., Shobin, E., Ferber, K. L., Gagnon, J., Rubel, C. E., Graham, D., Bateman, R. J., Holtzman, D. M., Huang, S., Yu, J., Yang, S. & Yarasheski, K. E., May 2023, In: Annals of Clinical and Translational Neurology. 10, 5, p. 765-778 14 p.Research output: Contribution to journal › Article › peer-review
- Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brainsMetabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brainsfor the Dominantly Inherited Alzheimer Network (DIAN) Study Group, the Alzheimer's Disease Neuroimaging Initiative, and the Alzheimer's Disease Metabolomics Consortium (ADMC), Novotny, B. C., Fernandez, M. V., Wang, C., Budde, J. P., Bergmann, K., Eteleeb, A. M., Bradley, J., Webster, C., Ebl, C., Norton, J., Gentsch, J., Dube, U., Wang, F., Morris, J., Bateman, R. J., Perrin, R. J., McDade, E., & 10 othersXiong, C., Chhatwal, J., Goate, A., Farlow, M., Schofield, P., Chui, H., Karch, C. M., Cruchaga, C., Benitez Viloria, B. A. & Harari, O., May 2023, […]
- CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s diseaseBarthélemy, N. R., Saef, B., Li, Y., Gordon, B. A., He, Y., Horie, K., Stomrud, E., Salvadó, G., Janelidze, S., Sato, C., Ovod, V., Henson, R. L., Fagan, A. M., Benzinger, T. L. S., Xiong, C., Morris, J. C., Hansson, O., Bateman, R. J. & Schindler, S. E., Apr 2023, In: Nature Aging. 3, 4, p. 391-401 11 p.Research output: Contribution to journal › Article › peer-review
- Confounding factors of Alzheimer's disease plasma biomarkers and their impact on clinical performancePichet Binette, A., Janelidze, S., Cullen, N., Dage, J. L., Bateman, R. J., Zetterberg, H., Blennow, K., Stomrud, E., Mattsson-Carlgren, N. & Hansson, O., Apr 2023, In: Alzheimer's and Dementia. 19, 4, p. 1403-1414 12 p.Research output: Contribution to journal › Article › peer-review
- Human striatal glia differentially contribute to AD- and PD-specific neurodegenerationXu, J., Farsad, H. L., Hou, Y., Barclay, K., Lopez, B. A., Yamada, S., Saliu, I. O., Shi, Y., Knight, W. C., Bateman, R. J., Benzinger, T. L. S., Yi, J. J., Li, Q., Wang, T., Perlmutter, J. S., Morris, J. C. & Zhao, G., Mar 2023, In: Nature Aging. 3, 3, p. 346-365 20 p.Research output: Contribution to journal › Article › peer-review