Featured publications

Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype

July 1, 2023

Lawler PE, Bollinger JG, Schindler SE, Hodge CR, Iglesias NJ, Krishnan V, Coulton JB, Li Y, Holtzman DM, Bateman RJ. Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype. Anal Biochem. 2023 Jul 1;672:115156. doi: 10.1016/j.ab.2023.115156. Epub 2023 Apr 16. PMID: 37072097.

Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer’s Disease

June 1, 2023

Horie K, Li Y, Barthélemy NR, Gordon B, Hassenstab J, Benzinger TLS, Fagan AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, Ikeuchi T, Kasuga K, Noble J, Farlow M, Chhatwal J, Day G, Schofield PR, Masters CL, Levin J, Jucker M, Lee JH, Roh JH, Sato C, Sachdev P, Koyama A, Reyderman L, Bateman RJ, McDade E; and the Dominantly Inherited Alzheimer Network. Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer’s Disease. Ann Neurol. 2023 Jun;93(6):1158-1172. doi: 10.1002/ana.26620. Epub 2023 Mar 16. PMID: 36843330; PMCID: PMC10238659.

Design and feasibility of an Alzheimer’s disease blood test study in a diverse community-based population

May 19, 2023

Li M, Li Y, Schindler SE, Yen D, Sutcliffe S, Babulal GM, Benzinger TLS, Lenze EJ, Bateman RJ. Design and feasibility of an Alzheimer’s disease blood test study in a diverse community-based population. Alzheimers Dement. 2023 May 19. doi: 10.1002/alz.13125. Epub ahead of print. PMID: 37204806.

CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease

April 1, 2023

Barthélemy NR, Saef B, Li Y, Gordon BA, He Y, Horie K, Stomrud E, Salvadó G, Janelidze S, Sato C, Ovod V, Henson RL, Fagan AM, Benzinger TLS, Xiong C, Morris JC, Hansson O, Bateman RJ, Schindler SE. CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease. Nat Aging. 2023 Apr;3(4):391-401. doi: 10.1038/s43587-023-00380-7. Epub 2023 Mar 13. PMID: 37117788; PMCID: PMC10154225.

Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS

March 10, 2023

Lucey BP, Liu H, Toedebusch CD, Freund D, Redrick T, Chahin SL, Mawuenyega KG, Bollinger JG, Ovod V, Barthélemy NR, Bateman RJ. Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS. Ann Neurol. 2023 Mar 10. doi: 10.1002/ana.26641. Epub ahead of print. PMID: 36897120.

Acute sleep loss decreases CSF-to-blood clearance of Alzheimer’s disease biomarkers

January 25, 2023

Liu H, Barthélemy NR, Ovod V, Bollinger JG, He Y, Chahin SL, Androff B, Bateman RJ, Lucey BP. Acute sleep loss decreases CSF-to-blood clearance of Alzheimer’s disease biomarkers. Alzheimers Dement. 2023 Jan 25. doi: 10.1002/alz.12930. Epub ahead of print. PMID: 36695437.

Recent publications

  • Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom OnsetLi, Y., Yen, D., Hendrix, R., Gordon, B., Dlamini, S., Barthélemy, N. R., Aschenbrenner, A. J., Henson, R. L., Herries, E. M., Volluz, K., Kirmess, K., Eastwood, S., Meyer, M., Heller, M., Jarrett, L., McDade, E., Holtzman, D. M., Benzinger, T. L. S., Morris, J., Bateman, R. J., & 2 othersXiong, C. & Schindler, S., 2024, (Accepted/In press) In: Annals of neurology.Research output: Contribution to journal › Article › peer-review
  • Neuropsychiatric Symptoms in AD: Clinical Trials Targeting Mild Behavioral Impairment: A Report from the International CTAD Task ForceSoto, M., Rosenberg, P., Ballard, C., Vellas, B., Miller, D., Gauthier, S., Carrillo, M. C., Lyketsos, C., Ismail, Z., Abushakra, S., Afshar, M., Agus, S., Aiden, P., Alam, J., Algeciras-Schimnich, A., Andrieu, S., Baruch, A., Bateman, R., Batrla, R., Baudler, M., & 83 othersBell, J., Bittner, T., Bozeat, S., Braunstein, J., Brooks, D., Brooks, T., Bullain, S., Burmeister, J., Carrillo, M., Cho, M., Collins, E., Cook, G., Dague, C., De Santi, S., Doody, R., Dunn, B., Egan, M., Eriksson, S., Esquivel, R., Fagan, […]
  • Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stagefor the Dominantly Inherited Alzheimer Network, 2024, (Accepted/In press) In: Alzheimer's and Dementia.Research output: Contribution to journal › Article › peer-review
  • Highly accurate blood test for Alzheimer’s disease is similar or superior to clinical cerebrospinal fluid testsBarthélemy, N. R., Salvadó, G., Schindler, S., He, Y., Janelidze, S., Collij, L. E., Saef, B., Henson, R. L., Chen, C. D., Gordon, B., Li, Y., La Joie, R., Benzinger, T. L. S., Morris, J., Mattsson-Carlgren, N., Palmqvist, S., Ossenkoppele, R., Rabinovici, G. D., Stomrud, E., Bateman, R., & 1 othersHansson, O., 2024, (Accepted/In press) In: Nature medicine.Research output: Contribution to journal › Article › peer-review
  • Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's diseaseWang, G., Li, Y., Xiong, C., Benzinger, T. L. S., Gordon, B., Hassenstab, J., Aschenbrenner, A. J., McDade, E., Clifford, D., Libre-Guerra, J. J., Shi, X., Mummery, C. J., van Dyck, C. H., Lah, J. J., Honig, L. S., Day, G., Ringman, J. M., Brooks, W. S., Fox, N. C., Suzuki, K., & 5 othersLevin, J., Jucker, M., Delmar, P., Bittner, T. & Bateman, R., 2024, (Accepted/In press) In: Alzheimer's and Dementia.Research output: Contribution to journal › Article › peer-review
  • Disease staging of Alzheimer’s disease using a CSF-based biomarker modelSalvadó, G., Horie, K., Barthélemy, N. R., Vogel, J. W., Pichet Binette, A., Chen, C. D., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Palmqvist, S., Stomrud, E., Janelidze, S., Ossenkoppele, R., Schindler, S. E., Bateman, R. J. & Hansson, O., 2024, (Accepted/In press) In: Nature Aging.Research output: Contribution to journal › Article › peer-review
  • Comparison of cerebrospinal fluid, plasma and neuroimaging biomarker utility in Alzheimer’s diseaseMeeker, K. L., Luckett, P. H., Barthélemy, N. R., Hobbs, D. A., Chen, C., Bollinger, J., Ovod, V., Flores, S., Keefe, S., Henson, R. L., Herries, E. M., McDade, E., Hassenstab, J. J., Xiong, C., Cruchaga, C., Benzinger, T. L. S., Holtzman, D. M., Schindler, S., Bateman, R. J., Morris, J., & 2 othersGordon, B. & Ances, B. M., 2024, In: Brain Communications. 6, 2Research output: Contribution to journal › Article › peer-review
  • Clinical validation of the PrecivityAD2 blood test: A mass spectrometry-based test with algorithm combining %p-tau217 and Aβ42/40 ratio to identify presence of brain amyloidMeyer, M. R., Kirmess, K. M., Eastwood, S., Wente-Roth, T. L., Irvin, F., Holubasch, M. S., Venkatesh, V., Fogelman, I., Monane, M., Hanna, L., Rabinovici, G. D., Siegel, B. A., Whitmer, R. A., Apgar, C., Bateman, R. J., Holtzman, D. M., Irizarry, M., Verbel, D., Sachdev, P., Ito, S., & 5 othersContois, J., Yarasheski, K. E., Braunstein, J. B., Verghese, P. B. & West, T., 2024, (Accepted/In press) In: Alzheimer's and Dementia.Research output: Contribution to journal › […]
  • Performance of the Lumipulse plasma Aβ42/40 and pTau181 immunoassays in the detection of amyloid pathologyFigdore, D. J., Wiste, H. J., Bornhorst, J. A., Bateman, R. J., Li, Y., Graff-Radford, J., Knopman, D. S., Vemuri, P., Lowe, V. J., Jr, C. R. J., Petersen, R. C. & Algeciras-Schimnich, A., Jan 1 2024, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 16, 1, e12545.Research output: Contribution to journal › Article › peer-review
  • Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer NetworkWagemann, O., Li, Y., Hassenstab, J., Aschenbrenner, A. J., McKay, N. S., Gordon, B. A., Benzinger, T. L. S., Xiong, C., Cruchaga, C., Renton, A. E., Perrin, R. J., Berman, S. B., Chhatwal, J. P., Farlow, M. R., Day, G. S., Ikeuchi, T., Jucker, M., Lopera, F., Mori, H., Noble, J. M., & 8 othersSánchez-Valle, R., Schofield, P. R., Morris, J. C., Daniels, A., Levin, J., Bateman, R. J., McDade, E. & Llibre-Guerra, J. J., Jan 2024, In: Alzheimer's and Dementia. 20, 1, p. 47-62 16 p.Research output: […]

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