Featured publications
Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype
July 1, 2023
Lawler PE, Bollinger JG, Schindler SE, Hodge CR, Iglesias NJ, Krishnan V, Coulton JB, Li Y, Holtzman DM, Bateman RJ. Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype. Anal Biochem. 2023 Jul 1;672:115156. doi: 10.1016/j.ab.2023.115156. Epub 2023 Apr 16. PMID: 37072097.
Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer’s Disease
June 1, 2023
Horie K, Li Y, Barthélemy NR, Gordon B, Hassenstab J, Benzinger TLS, Fagan AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, Ikeuchi T, Kasuga K, Noble J, Farlow M, Chhatwal J, Day G, Schofield PR, Masters CL, Levin J, Jucker M, Lee JH, Roh JH, Sato C, Sachdev P, Koyama A, Reyderman L, Bateman RJ, McDade E; and the Dominantly Inherited Alzheimer Network. Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer’s Disease. Ann Neurol. 2023 Jun;93(6):1158-1172. doi: 10.1002/ana.26620. Epub 2023 Mar 16. PMID: 36843330; PMCID: PMC10238659.
Design and feasibility of an Alzheimer’s disease blood test study in a diverse community-based population
May 19, 2023
Li M, Li Y, Schindler SE, Yen D, Sutcliffe S, Babulal GM, Benzinger TLS, Lenze EJ, Bateman RJ. Design and feasibility of an Alzheimer’s disease blood test study in a diverse community-based population. Alzheimers Dement. 2023 May 19. doi: 10.1002/alz.13125. Epub ahead of print. PMID: 37204806.
CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease
April 1, 2023
Barthélemy NR, Saef B, Li Y, Gordon BA, He Y, Horie K, Stomrud E, Salvadó G, Janelidze S, Sato C, Ovod V, Henson RL, Fagan AM, Benzinger TLS, Xiong C, Morris JC, Hansson O, Bateman RJ, Schindler SE. CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease. Nat Aging. 2023 Apr;3(4):391-401. doi: 10.1038/s43587-023-00380-7. Epub 2023 Mar 13. PMID: 37117788; PMCID: PMC10154225.
Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS
March 10, 2023
Lucey BP, Liu H, Toedebusch CD, Freund D, Redrick T, Chahin SL, Mawuenyega KG, Bollinger JG, Ovod V, Barthélemy NR, Bateman RJ. Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS. Ann Neurol. 2023 Mar 10. doi: 10.1002/ana.26641. Epub ahead of print. PMID: 36897120.
Acute sleep loss decreases CSF-to-blood clearance of Alzheimer’s disease biomarkers
January 25, 2023
Liu H, Barthélemy NR, Ovod V, Bollinger JG, He Y, Chahin SL, Androff B, Bateman RJ, Lucey BP. Acute sleep loss decreases CSF-to-blood clearance of Alzheimer’s disease biomarkers. Alzheimers Dement. 2023 Jan 25. doi: 10.1002/alz.12930. Epub ahead of print. PMID: 36695437.
Recent publications
- A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer’s DiseaseGalasko, D., Farlow, M. R., Lucey, B. P., Honig, L. S., Elbert, D., Bateman, R., Momper, J., Thomas, R. G., Rissman, R. A., Pa, J., Aslanyan, V., Balasubramanian, A., West, T., Maccecchini, M. & Feldman, H. H., Dec 2024, In: Alzheimer's Research and Therapy. 16, 1, 151.Research output: Contribution to journal › Article › peer-review
- Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individualsXiong, C., Luo, J., Wolk, D. A., Shaw, L. M., Roberson, E. D., Murchison, C. F., Henson, R. L., Benzinger, T. L. S., Bui, Q., Agboola, F., Grant, E., Gremminger, E. N., Moulder, K. L., Geldmacher, D. S., Clay, O. J., Babulal, G., Cruchaga, C., Holtzman, D. M., Bateman, R. J. & Morris, J. C. & 1 others, Schindler, S. E., Dec 2024, In: Nature communications. 15, 1, 5539.Research output: Contribution to journal › Article › peer-review
- Predicting continuous amyloid PET values with CSF tau phosphorylation occupanciesWisch, J. K., Gordon, B. A., Barthélemy, N. R., Horie, K., Henson, R. L., He, Y., Flores, S., Benzinger, T. L. S., Morris, J. C., Bateman, R. J., Ances, B. M. & Schindler, S. E., Sep 2024, In: Alzheimer's and Dementia. 20, 9, p. 6365-6373 9 p.Research output: Contribution to journal › Article › peer-review
- An interpretable machine learning-based cerebrospinal fluid proteomics clock for predicting age reveals novel insights into brain agingMelendez, J., Sung, Y. J., Orr, M., Yoo, A., Schindler, S., Cruchaga, C. & Bateman, R., Sep 2024, In: Aging Cell. 23, 9, e14230.Research output: Contribution to journal › Article › peer-review
- Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis PatientsBrier, M. R., Schindler, S. E., Salter, A., Perantie, D., Shelley, N., Judge, B., Keefe, S., Kirmess, K. M., Verghese, P. B., Yarasheski, K. E., Venkatesh, V., Raji, C. A., Gordon, B. A., Bateman, R. J., Morris, J. C., Naismith, R. T., Holtzman, D. M., Benzinger, T. L. S. & Cross, A. H., Sep 2024, In: Annals of neurology. 96, 3, p. 453-459 7 p.Research output: Contribution to journal › Article › peer-review
- A genetic and proteomic comparison of key AD biomarkers across tissuesDominantly Inherited Alzheimer Network, Marsh, T. W., Western, D., Timsina, J., Gorijala, P., Yang, C., Pastor, P., Liu, M., Morris, J. C., Bateman, R. J., Schindler, S. E., Sung, Y. J. & Cruchaga, C., Sep 2024, In: Alzheimer's and Dementia. 20, 9, p. 6423-6440 18 p.Research output: Contribution to journal › Article › peer-review
- Statistical considerations when estimating time-saving treatment effects in Alzheimer's disease clinical trialsWang, G., Cutter, G., Oxtoby, N. P., Shan, G., Wang, W., Mangal, B., Liao, Y., Llibre-Guerra, J. J., Li, Y., Xiong, C., McDade, E., Delmar, P., Bateman, R. J. & Schneider, L., Aug 2024, In: Alzheimer's and Dementia. 20, 8, p. 5421-5433 13 p.Research output: Contribution to journal › Article › peer-review
- Novel non-linear models for clinical trial analysis with longitudinal data: A tutorial using SAS for both frequentist and Bayesian methodsWang, G., Wang, W., Mangal, B., Liao, Y., Schneider, L., Li, Y., Xiong, C., McDade, E., Kennedy, R., Bateman, R. & Cutter, G., Jul 10 2024, In: Statistics in medicine. 43, 15, p. 2987-3004 18 p.Research output: Contribution to journal › Article › peer-review
- Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical TrialWagemann, O., Liu, H., Wang, G., Shi, X., Bittner, T., Scelsi, M. A., Farlow, M. R., Clifford, D. B., Supnet-Bell, C., Santacruz, A. M., Aschenbrenner, A. J., Hassenstab, J. J., Benzinger, T. L. S., Gordon, B. A., Coalier, K. A., Cruchaga, C., Ibanez, L., Perrin, R. J., Xiong, C. & Li, Y. & 30 others, Morris, J. C., Lah, J. J., Berman, S. B., Roberson, E. D., Van Dyck, C. H., Galasko, D., Gauthier, S., Hsiung, G. Y. R., Brooks, W. S., Pariente, J., […]
- Use of a Blood Biomarker Test Improves Economic Utility in the Evaluation of Older Patients Presenting with Cognitive ImpairmentCanestaro, W. J., Bateman, R. J., Holtzman, D. M., Monane, M. & Braunstein, J. B., Jun 1 2024, In: Population Health Management. 27, 3, p. 174-184 11 p.Research output: Contribution to journal › Article › peer-review