Featured publications
Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype
July 1, 2023
Lawler PE, Bollinger JG, Schindler SE, Hodge CR, Iglesias NJ, Krishnan V, Coulton JB, Li Y, Holtzman DM, Bateman RJ. Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype. Anal Biochem. 2023 Jul 1;672:115156. doi: 10.1016/j.ab.2023.115156. Epub 2023 Apr 16. PMID: 37072097.
Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer’s Disease
June 1, 2023
Horie K, Li Y, Barthélemy NR, Gordon B, Hassenstab J, Benzinger TLS, Fagan AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, Ikeuchi T, Kasuga K, Noble J, Farlow M, Chhatwal J, Day G, Schofield PR, Masters CL, Levin J, Jucker M, Lee JH, Roh JH, Sato C, Sachdev P, Koyama A, Reyderman L, Bateman RJ, McDade E; and the Dominantly Inherited Alzheimer Network. Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer’s Disease. Ann Neurol. 2023 Jun;93(6):1158-1172. doi: 10.1002/ana.26620. Epub 2023 Mar 16. PMID: 36843330; PMCID: PMC10238659.
Design and feasibility of an Alzheimer’s disease blood test study in a diverse community-based population
May 19, 2023
Li M, Li Y, Schindler SE, Yen D, Sutcliffe S, Babulal GM, Benzinger TLS, Lenze EJ, Bateman RJ. Design and feasibility of an Alzheimer’s disease blood test study in a diverse community-based population. Alzheimers Dement. 2023 May 19. doi: 10.1002/alz.13125. Epub ahead of print. PMID: 37204806.
CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease
April 1, 2023
Barthélemy NR, Saef B, Li Y, Gordon BA, He Y, Horie K, Stomrud E, Salvadó G, Janelidze S, Sato C, Ovod V, Henson RL, Fagan AM, Benzinger TLS, Xiong C, Morris JC, Hansson O, Bateman RJ, Schindler SE. CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease. Nat Aging. 2023 Apr;3(4):391-401. doi: 10.1038/s43587-023-00380-7. Epub 2023 Mar 13. PMID: 37117788; PMCID: PMC10154225.
Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS
March 10, 2023
Lucey BP, Liu H, Toedebusch CD, Freund D, Redrick T, Chahin SL, Mawuenyega KG, Bollinger JG, Ovod V, Barthélemy NR, Bateman RJ. Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS. Ann Neurol. 2023 Mar 10. doi: 10.1002/ana.26641. Epub ahead of print. PMID: 36897120.
Acute sleep loss decreases CSF-to-blood clearance of Alzheimer’s disease biomarkers
January 25, 2023
Liu H, Barthélemy NR, Ovod V, Bollinger JG, He Y, Chahin SL, Androff B, Bateman RJ, Lucey BP. Acute sleep loss decreases CSF-to-blood clearance of Alzheimer’s disease biomarkers. Alzheimers Dement. 2023 Jan 25. doi: 10.1002/alz.12930. Epub ahead of print. PMID: 36695437.
Recent publications
- Cognitive impact of multidomain intervention and omega 3 according to blood Aβ42/40 ratio: a subgroup analysis from the randomized MAPT trialDelrieu, J., Vellas, B., Guyonnet, S., Cantet, C., Ovod, V., Li, Y., Bollinger, J., Bateman, R. & Andrieu, S., Dec 2023, In: Alzheimer's Research and Therapy. 15, 1, 183.Research output: Contribution to journal › Article › peer-review
- Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer diseaseKnight Alzheimer Disease Research Center (Knight ADRC), the Dominantly Inherited Alzheimer Network (DIAN), Alzheimer’s Disease Neuroimaging Initiative (ADNI), ADNI-DOD, A4 Study Team, the Australian Imaging Biomarkers, Lifestyle (AIBL) Study, Ali, M., Archer, D. B., Gorijala, P., Western, D., Timsina, J., Fernández, M. V., Chen, G., Gordon, B., Benzinger, T. L. S., Xiong, C., Morris, J. C., Bateman, R. J., Karch, C. M., McDade, E., Sung, Y. J., & 1 othersCruchaga, C., Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 68.Research output: Contribution to journal › Article › peer-review
- Tau accumulation in autosomal dominant Alzheimer’s disease: a longitudinal [18F]flortaucipir studyO’Connor, A., Cash, D. M., Poole, T., Markiewicz, P. J., Fraser, M. R., Malone, I. B., Jiao, J., Weston, P. S. J., Flores, S., Hornbeck, R., McDade, E., Schöll, M., Gordon, B. A., Bateman, R. J., Benzinger, T. L. S. & Fox, N. C., Dec 2023, In: Alzheimer's Research and Therapy. 15, 1, 99.Research output: Contribution to journal › Article › peer-review
- A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer’s diseaseMerrihew, G. E., Park, J., Plubell, D., Searle, B. C., Keene, C. D., Larson, E. B., Bateman, R., Perrin, R. J., Chhatwal, J. P., Farlow, M. R., McLean, C. A., Ghetti, B., Newell, K. L., Frosch, M. P., Montine, T. J. & MacCoss, M. J., Dec 2023, In: Scientific data. 10, 1, 206.Research output: Contribution to journal › Article › peer-review
- Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriersDominantly Inherited Alzheimer Network (DIAN), Brase, L., You, S. F., D’Oliveira Albanus, R., Novotny, B. C., Soriano-Tarraga, C., Dykstra, T., Fernandez, M. V., Budde, J. P., Bergmann, K., Morris, J. C., Bateman, R. J., Perrin, R. J., McDade, E., Xiong, C., Kipnis, J., Karch, C. M., Benitez, B. A. & Harari, O., Dec 2023, In: Nature communications. 14, 1, 2314.Research output: Contribution to journal › Article › peer-review
- Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers. Results from the DIAN studyDominantly Inherited Alzheimer Network (DIAN), Xu, Y., Aung, H. L., Bateman, R. J., Brooks, W. S., Chhatwal, J., Day, G., Fagan, A. M., Farlow, M. R., Gordon, B., Kehoe, P. G., Levin, J., Mori, H., Morris, J., Wharton, W., Humburg, P., Schofield, P. R. & Peters, R., Nov 2023, In: Alzheimer's and Dementia. 19, 11, p. 4999-5009 11 p.Research output: Contribution to journal › Article › peer-review
- Chronic GCPII (glutamate-carboxypeptidase-II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaquesBathla, S., Datta, D., Liang, F., Barthelemy, N., Wiseman, R., Slusher, B. S., Asher, J., Zeiss, C., Ekanayake-Alper, D., Holden, D., Terwilliger, G., Duque, A., Arellano, J., van Dyck, C., Bateman, R. J., Xie, Z., Nairn, A. C. & Arnsten, A. F. T., Oct 1 2023, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 9, 4, e12431.Research output: Contribution to journal › Article › peer-review
- Can We Use Blood Biomarkers as Entry Criteria and for Monitoring Drug Treatment Effects in Clinical Trials? A Report from the EU/US CTAD Task ForceEU/US/CTAD Task Force, Sep 2023, In: The journal of prevention of Alzheimer's disease. 10, 3, p. 418-425 8 p.Research output: Contribution to journal › Article › peer-review
- Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s diseasethe Dominantly Inherited Alzheimer Network, Aug 2023, In: Nature medicine. 29, 8, p. 1979-1988 10 p.Research output: Contribution to journal › Article › peer-review
- Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's diseaseSchultz, S. A., Shirzadi, Z., Schultz, A. P., Liu, L., Fitzpatrick, C. D., McDade, E., Barthelemy, N. R., Renton, A., Esposito, B., Joseph-Mathurin, N., Cruchaga, C., Chen, C. D., Goate, A., Allegri, R. F., Benzinger, T. L. S., Berman, S., Chui, H. C., Fagan, A. M., Farlow, M. R., Fox, N. C., & 27 othersGordon, B. A., Day, G. S., Graff-Radford, N. R., Hassenstab, J. J., Hanseeuw, B. J., Hofmann, A., Jack, C. R., Jucker, M., Karch, C. M., Koeppe, R. A., Lee, […]
